Histones

Histones is part of ENA Profile with other 16 tests dsDNA  Nucleosome  Histones  SmD1  PCNA  P0  SS-A/Ro60  SS-A/Ro52  SS-B/La  CENP-B  Scl70  U1-snRNP  AMAM2  Jo-1  PM-Scl  Mi-2  ku

Antibodies to one or several types of histones or to the H2A-H2B complex are constantly found in medication –drug induced lupus erythematosus (procainamide, hydralazine, Isoniazid, Chlorpromazine, Methyldopa, Anti Convulsants, Sulfasalazine, Captopryl and Beta Blockers). Histones are also found in 30%-70% of patients with disseminated lupus erythematosus and in 15%- 50% of patients with rheumatoid arthritis. In absence of other autoantibodies, especially Sm and dsDNA, is considered a high possible Drug Induced Lupus

Reporting Time 48 Hrs

Fasting Time 0 Hrs

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